Effect Of Silybum Marianum Seed Extracts On Biochemical Profile In Rabbit Liver

In the present study the hepatogenic effect of S. marianum seeds was evaluated against paracetamol induced hepatotoxicity in rabbit. Aqueous extract (AqE) and petroleum ether extract (PEE) of S. marianum seeds were administered @ 1000 mg/kg body weight orally daily from 3rd to 7th day of experiment to different groups of albino rabbits paracetamol (500 mg/kg, once orally on 1st day) was administered. The PEE of S. marianum seeds significantly (P<0.05) decreased the enhanced levels of serum alkaline phosphatase (SAP), serum arginase (SARG), glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) due to paracetamol administration. However, the AqE of S. marianum seeds significantly counteracted the paracetamol induced elevation of SARG and SGPT. The paracetamol mediated reduction in the levels of serum total protein (STP), and its fractions (viz., albumin, globulin and albumin/globulin ratio) was elevated by S. marianum seed extracts. The results suggest that the extracts of S. marianum seeds may protect the liver from damaged by various hepatotoxicants.