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Home▶ Journals▶ Indian Journal of Veterinary Sciences and Biotechnology▶Archive▶Vol. 22 No. 3 (2026)▶Effects of Xylazine and Dexmedetomidine as a Preanaesthetic…
Indian Journal of Veterinary Sciences and Biotechnology
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Research Article

Effects of Xylazine and Dexmedetomidine as a Preanaesthetic Agent with Tiletamine-Zolazepam Anaesthesia on Clinico -Haemato-Biochemical Profile in Dogs

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Ishan B Dharmapal — Department of Veterinary Surgery and Radiology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Junagadh-362001, Gujarat, India
Jignesh V Vadalia — Assistant Professor & Head, Department of Veterinary Surgery and Radiology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Anand-388001, India.
Karsan B Vala — Department of Veterinary Gynaecology and Obstetrics, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Junagadh-362 001, Gujarat, India
Amitkumar R Bhadaniya — Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Anand-388 001, Gujarat, India
Nilesh R Padaliya — Department of Veterinary Surgery and Radiology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Junagadh-362001, Gujarat, India
Published 21 Apr 2026 Vol. 22 No. 3 (2026), pp. 147-152 ● Open access
❝ How to cite 🔗 https://doi.org/10.48165/ijvsbt.22.3.28
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Abstract

The present clinical study assessed the clinico-physiological and haemato-biochemical effects of xylazine and dexmedetomidine as  preanaesthetic agents in dogs anaesthetised with tiletamine-zolazepam. A total of 12 dogs were presented for major surgical procedures.  They were randomly divided into two groups: Group I received xylazine (@ 1 mg/kg BW, IM) and Group II received dexmedetomidine  (@ 0.01 mg/kg BW, IM), followed by intravenous induction with tiletamine-zolazepam (@ 3 mg/kg BW till effect) and maintenance with  the same @ one-half of induction dose. Clinico-physiological and haemato-biochemical parameters were recorded before, during and  at 15 minutes intervals post-induction. Both anaesthetic protocols maintained cardiovascular and respiratory stability, time-dependent  variations observed within groups. No significant differences were noted between groups, indicating well-preserved cardiac function  and overall cardiovascular health. Haemato-biochemical parameters showed fluctuations but remained within normal physiological  limits confirming adequate hepatic and renal safety. 

 

KeywordsClinico-physiological parameters, Dexmedetomidine, Dogs, Haemato-biochemical parameters, T-Z Anaesthesia, Xylazine.

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