Preparation And Characterization Of Ceftiofur-Loaded Zinc Oxide Nanoparticles (Zno Nps)
DOI:
https://doi.org/10.48165/jvls.2025.1.2.4Abstract
Nanotechnology is a scientific field focused on the manipulation of matter at the nanometer scale. Nanoparticles have achieved significant attention in drug-delivery applications because of their small size and large a surface-area-to-volume ratio, which enable improved drug loading and controlled release. These features offer the potential to overcome limitations associated with conventional drug formulations and enhance therapeutic efficiency. In this research, we used sol-gel method to produce zinc oxide nanoparticles, using zinc acetate as a precursor. Ceftiofur, the antibiotic of interest, was subsequently loaded into the nanoparticles, and the resulting samples were freeze-dried. Both blank and ceftiofur-loaded nanoparticles were characterized using dynamic light scattering to determine particle size, polydispersity index (PDI), and zeta potential, and transmission electron microscopy to assess morphology. The prepared blank zinc oxide nanoparticles exhibited an average diameter of 245.8 nm, a PDI of 0.621, and a zeta potential of +26.23 mV. The ceftiofur-loaded nanoparticles showed a slightly larger diameter of 288.13 nm, a PDI of 0.609, and a zeta potential of +27.16 mV. Transmission electron microscopy revealed that both nanoparticle types were nearly spherical in shape, confirming successful synthesis and drug loading.Downloads
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