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Home▶ Journals▶ Indian Journal of Veterinary Sciences and Biotechnology▶Archive▶Vol. 19 No. 2 (2023)▶Genomic Sequence and Phylogenetic analysis of Canine…
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Genomic Sequence and Phylogenetic analysis of Canine Parvovirus New 2a Variant Strain in Indian Dogs

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Yuvachandran Viva Vimalan — Department of Animal Biotechnology, Faculty of Basic Sciences, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai-600 007.
Raja Paramasivam — Department of Veterinary Pathology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai-600 007.
Parthiban Manoharan — Department of Animal Biotechnology, Faculty of Basic Sciences, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai-600 007.
Maha Prabhu Ramalingam — Department of Veterinary Pathology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai-600 007.
Parthiban Sivamurthy — Department of Animal Biotechnology, Faculty of Basic Sciences, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai-600 007.
Parthiban Sivamurthy — Department of Animal Biotechnology, Faculty of Basic Sciences, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai-600 007.
Sathish Gopal — Department of Animal Biotechnology, Faculty of Basic Sciences, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai-600 007.
Sarathchandra Ghadevaru — Dean, Faculty of Basic Sciences, Madras Veterinary College Campus, Tamil Nadu Veterinary and Animal Sciences University, Chennai-600 007.
Published 2 Mar 2023 Vol. 19 No. 2 (2023), pp. 47-53 ● Open access
❝ How to cite 🔗 https://doi.org/10.48165/ijvsbt.19.2.09
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Abstract

In this study, a virulent field canine parvovirus type - 2a variant (CPV-new 2a) strain, ABT/CPV/MVC02, was identified from the faeces of a Dog with severe haemorrhagic gastroenteritis in Chennai, Tamil Nadu, India. The genomic sequence of ABT/CPV/MVC02 (MN661243) shares 99.33% nucleotide identity with those of CPV new 2a variant strains. Based on the VP2 capsid protein amino acid variation (Ser297Ala), the ABT/CPV/MVC02 strain is classified as a new CPV 2a variant strain. Two VP2 mutations Tyr324Ile and Thr440Ala were reported in most of the CPV-2a stains also present in ABT/CPV/MVC02.The phylogenetic analysis of the reported strain revealed that it was distinct from existing CPV 2a strains from India and other countries. This complete genomic analysis revealed that the CPV-2a new variant strain circulating in India is evolving rapidly with unique antigenic variations between field CPV-2a and vaccine strains which may be the major cause for vaccine failure in vaccinated dogs.

KeywordsCanine parvovirus (CPV)CPV-2a StrainCPV-2bCPV-2c and Genomic Sequence

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