Haemato-Biochemical Changes in Dermatitis Associated with Penicillium spp. in Dogs
DOI:
https://doi.org/10.48165/ijvsbt.2026.22.06.19Keywords:
Dermatitis, Dogs, Haemato-biochemical profile, Penicillium spp, TherapyAbstract
Skin infection in dogs is classified as primary infection, caused by infectious organisms directly and secondary infections, which are augmented by underlying conditions that act as catalysts for infections such as bacterial or fungal infections. Among fungal infections, Penicillium is one of the largest genera. Penicillium species can cause allergies and both superficial and invasive infections. Keeping the above facts in view, the present research was undertaken to study the haemato-biochemical alterations in clinically affected dogs with Penicillium spp. associated dermatitis. A total of 200 dogs were selected for the study. Skin scraping samples were collected for culture and microscopic identification. Out of 200 dogs screened, 23 (11.5%) dogs were found positive for Penicillium-associated dermatitis based on skin scraping, Penicillium culture and identification. Penicillium-associated dermatitis in dogs revealed an increase in TLC, lymphocytes, eosinophils and total protein, and a decrease in serum zinc and copper concentration. On the basis of heamato-biochemical profile group T₁ showed better recovery. Twelve positive dogs, 6 each, treated with Tab. Terbinafine @ 30 mg/kg b.wt. (T1), and Tab. Itraconazole @ 10 mg/kg b.wt. (T2), PO, OD, for 21 days, with supportive therapy, resulted in normalization of these altered profiles by day 28 of treatment, at par with healthy control group, (T3, n=6). Basis of clinical recovery and haemato-biochemical analysis treatment Tab. Terbinafine showed better results from Penicillium-associated canine dermatitis.
Downloads
References
Ambily, V. R., Usha, N. P., Ajithkumar, S., Deepa, C., David, P., Maya, S., Aravindakshan, T. V., & Krishna, B. D. (2022). A prospective study on haematobiochemical aspects of atopic dermatitis in dogs. Journal of Veterinary and Animal Sciences, 53(4), 731–739.
Aujla, R. S., Singh, N., Jand, S. K., Sodhi, S., Sood, N., & Gupta, P. P. (1999). Mycotic dermatitis in dogs in Punjab: Clinico-pathological studies. Indian Journal of Comparative Microbiology Immunology and Infectious Diseases, 20(2), 134–136.
Beigh, S. A., Soodan, J. S., Singh, R., Khan, A. M., & Dar, M. A. (2014). Evaluation of trace elements, oxidant/antioxidant status, vitamin C and β-carotene in dogs with dermatophytosis. Mycoses, 57, 358–365.
Brar, R. K., Dhaliwal, P. S., Kumar, A., Chhabra, S., & Uppal, S. K. (2017). Clinico-pathological studies on atopic dermatitis in dogs. Journal of Animal Research, 7(3), 507–513.
Dina, A. A. M. (2021). Clinical and laboratory studies on diagnosis of most common skin diseases in dogs and cats [Doctoral dissertation, Suez Canal University, Ismailia, Egypt].
El-Motaily, N. M., Farag, H. S., Abdou, O. M., Saber, M., & Ahmed, K. A. (2022). The relationship between antioxidant trace elements (Zn-Cu and Se) and oxidative stress in dogs affected with dermatophytosis. International Journal of Veterinary Science, 11(4), 467–473.
García, L. F. (2020). Immune response, inflammation, and the clinical spectrum of COVID-19. Frontiers in Immunology, 11, Article 1441, 1–13.
Gong, S., Babitha, V., Ramnath, V. R., Beena, V., & Unny, N. M. (2023). Evaluation of serum mineral status in dermatological disorders of dogs. Journal of Veterinary and Animal Sciences, 54(2), 354–359.
Hefnawy, A. E., & El-Khaiat, H. M. (2015). The importance of copper and the effects of its deficiency and toxicity in animal health. International Journal of Livestock Research, 5, 1–20.
Joshi, P. J. (2019). Clinico-therapeutic studies on canine mycotic dermatitis [M.V.Sc. thesis, G. B. Pant University of Agriculture & Technology, Pantnagar, Uttarakhand, India].
Langlois, D. K., Sutton, D. A., Swenson, C. L., Bailey, C. J., Wiederhold, N. P., Nelson, N. C., & Peterson, S. W. (2014). Clinical, morphological, and molecular characterization of Penicillium canis sp. nov., isolated from a dog with osteomyelitis. Journal of Clinical Microbiology, 52(7), 2447–2453.
Meason-Smith, C., Olivry, T., Lawhon, S. D., & Hoffmann, A. R. (2020). Malassezia species dysbiosis in natural and allergen-induced atopic dermatitis in dogs. Medical Mycology, 58(6), 756–765.
Miyakawa, K., Swenson, C. L., Mendoza, L., Boyle, M. H., & Steficek, B. A. (2011). Pathology in practice. Journal of the American Veterinary Medical Association, 238(1), 51–53.
Nair, S. S., & Nauriyal, D. S. (2007). Diagnostic significance of haematological changes associated with various canine dermatoses. Intas Polivet, 8(1), 68–72.
Narang, A., Arora, N., Rajora, V. S., Mrigesh, M., Das, A. K., & Krishan, G. (2015). Haematological and biochemical studies on dermatoses in canines. Indian Journal of Veterinary Sciences & Biotechnology, 10(4), 48–51.
Pandey, P. K. (2024). Study on fungal dermatitis in dogs with reference to therapeutic intervention with Henna (Lawsonia inermis) leaves extract [M.V.Sc. thesis, Bihar Animal Sciences University, Patna, Bihar, India].
Pond, W. G., Church, D. B., Pond, K. R., & Schoknecht, P. A. (2004). Basic animal nutrition and feeding (5th ed.). John Wiley & Sons.
Remi, R. A., Thoha, T. B., Adefolake, O. O., Sikirat, M. O., & Oluwadun, A. (2012). Investigation on some haematological parameters and the biochemical system in pupils with dermatophytosis. Report and Opinion, 4, 67–69.
Scott, D. W., Miller, W. H., & Griffin, C. E. (2001). Small animal dermatology (6th ed.). W. B. Saunders.
Seker, E., & Dogan, N. (2011). Isolation of dermatophytes from dogs and cats with suspected dermatophytosis in Western Turkey. Preventive Veterinary Medicine, 98(1), 46–51.
Sharma, J., Mudalagiriyappa, S., & Nanjappa, S. G. (2022). T cell responses to control fungal infection in an immunological memory lens. Frontiers in Immunology, 13, 1–21.
Sharma, R., Hussain, K., Batoo, A. S., Chaudhary, S., Kour, S., Chibber, S., & Bhat, M. A. (2017). Biomarkers of oxidative stress in canine dermatitis. Journal of Animal Research, 7, 567–570.
Sharma, S. K., Soodan, J. S., Raina, B. B., Gupta, S. K., & Yadav, A. (2008). Prevalence of skin infection in canines. Indian Journal of Veterinary Medicine, 28, 137–138.
Simpanya, M. F., & Baxter, M. (1996). Isolation of fungi from the pelage of cats and dogs using the hairbrush technique. Mycopathologia, 134, 129–133.
Sindha, M. J., Trangadia, B. J., Vihol, P. D., Parmar, R. S., & Patel, B. V. (2015). Clinico-pathological evaluation of non-parasitic dermatoses in canines. Veterinary World, 8(11), 1346–1350.
Snedecor, G. W., & Cochran, W. G. (1994). Statistical methods (8th ed.). Iowa State University Press.
Soad, A., Abdou, O. M., Ahmed, K. A., & Farag, H. S. (2021). Haematological, biochemical and histopathological studies on selected canine skin diseases. Veterinary Medical Journal (Giza), 67(1), 69–94.
Stockham, S. L., Keeton, K. S., & Szladovits, B. (2003). Clinical assessment of leukocytosis: Distinguishing leukocytoses caused by inflammatory, glucocorticoid, physiologic, and leukemic disorders or conditions. Veterinary Clinics: Small Animal Practice, 33(6), 1335–1357.
Ural, K., Karakurum, M. C., Duru, O., Cingi, C., & Haydardedeoglu, A. E. (2009). Serum zinc concentrations in dogs with Microsporum canis dermatophytosis: A pilot study. Turkish Journal of Veterinary and Animal Sciences, 33, 279–283.
Würsch, K., Brachelente, C., Doherr, M., Reist, M., Sattler, U., & Forster Welle, M. (2006). Immune dysregulation in flea allergy dermatitis: A model for the immunopathogenesis of allergic dermatitis. Veterinary Immunology and Immunopathology, 110(3–4), 311–323.
Published
Issue
Section
License
Copyright (c) 2026 Indian Journal of Veterinary Sciences and Biotechnology
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
