Ozone as an Adjunct Therapy in Canine Parvo Virus Infection in Dogs
DOI:
https://doi.org/10.48165/ijvsbt.22.4.16Keywords:
Adjunct therapy, Canine parvo virus, OzoneAbstract
Canine Parvovirus infection is highly infectious disease of younger dogs with high mortality rates. A total of 1026 dogs presented at Veterinary Clinical Complex of the College in Shirwal were screened, out of which 33 dogs (3.2%) were confirmed positive for CPV using rapid antigen test, which were further confirmed by PCR. Twenty affected dogs were selected and divided into two treatment groups: Group 2 (standard ceftriaxone + supportive therapy) and Group 3 (ozonated RL as an adjunct therapy along with standard treatment), each comprising 10 animals, while 10 healthy dogs served as control Group-I. Haematological findings revealed a significant (p<0.05) decrease in Hb, PCV, TEC, TLC and platelet values in all the affected dogs compared with the healthy control group. Biochemical findings revealed significantly (p<0.05) increased ALT, AST, ALP, bilirubin, creatinine and BUN values, while significant decrease in total protein, Na, K, Cl and glucose levels in CPV affected dogs. Dogs received ozone therapy (Group 3) showed better recovery with mean recovery period of 4.6 days as compared to 5.9 days in Group 2 dogs. Further dogs treated with ozone therapy reported faster restoration of clinico-haemato-biochemical values compared to standard antibiotic therapy in CPV infected dogs.
Downloads
References
Abdullaziz, I., Aly, M., & ElShahawy, I. (2022). Clinical, haemato-biochemical alterations with acute phase response in canine parvoviral enteritis. Damanhour Journal of Veterinary Sciences, 7(1), 23–27.
Castro, T. X., Rita de Cássia, N., Gonçalves, L. P., Costa, E. M., Marcello, G. C., Labarthe, N. V., & Mendes-de-Almeida, F. (2013). Clinical, hematological, and biochemical findings in puppies with coronavirus and parvovirus enteritis. The Canadian Veterinary Journal, 54(9), 885.
Desai, D., Kalyani, I., Ramani, U., Makwana, P., Patel, D., & Vala, J. (2020). Evaluation of three different methods of viral DNA extraction for molecular detection of canine parvovirus-2 from faecal samples of dogs. Journal of Entomology and Zoology Studies, 8(3), 479–481.
Dogra, S., & Sood, N. K. (2016). Haemato-biochemical alterations in canine parvovirus infection. Indian Journal of Veterinary Pathology, 40(3), 226–228.
Dos Santos, T. G., Orlandin, J. R., de Almeida, M. F., Scassiotti, R. F., Oliveira, V. C., Santos, S. I. P., Pereira, V. M., Pinto, P. A. F., Mariano, C. G., & Ambrósio, C. E. (2023). Ozone therapy: Protocol for treating canine parvovirus infection. Brazilian Journal of Veterinary Medicine, 45, e004622.
Dupont, N., Jessen, L. R., Moberg, F., Zyskind, N., Lorentzen, C., & Bjørnvad, C. R. (2021). A retrospective study of 237 dogs hospitalized with suspected acute hemorrhagic diarrhea syndrome: Disease severity, treatment, and outcome. Journal of Veterinary Internal Medicine, 35(2), 867–877.
Elvis, A. M., & Ekta, J. S. (2011). Ozone therapy: A clinical review. Journal of Natural Science, Biology, and Medicine, 2(1), 66.
Haque, S., & Tayyaba, A. (2011). Studies on incidence of parvo gastroenteritis and its treatment by different concentration of fluid in pups. Indian Journal of Canine Practice, 3(2), 80–82.
Kalli, I., Leontides, L. S., Mylonakis, M. E., Adamama-Moraitou, K., Rallis, T., & Koutinas, A. F. (2010). Factors affecting the occurrence, duration of hospitalization and final outcome in canine parvovirus infection. Research in Veterinary Science, 89(2), 174–178.
Khare, D. S., Gupta, D. K., Shukla, P. C., Das, G., Meena, N. S., & Khare, R. (2020). Clinical and haemato-biochemical changes in canine parvovirus infection. Journal of Pharmacognosy and Phytochemistry, 9(4), 1601–1604.
Khatri, R., Poonam, M. H., & Minakshi, P. C. (2017). Epidemiology, pathogenesis, diagnosis and treatment of canine parvovirus disease in dogs: A mini review. Journal of Veterinary Sciences and Medical Diagnosis, 6(3), 2.
Ogbu, K. I., Chukwudi, C. I., Tion, M. T., Eze, U. U., Nwosuh, I. C., & Anene, B. M. (2022). Haematology and serum biochemistry of dogs naturally infected with canine parvovirus-2. Sokoto Journal of Veterinary Sciences, 20(5), 141–152.
Ramprabhu, R., Prathaban, S., Nambi, A. P., & Dhanapalan, P. (2002). Haemorrhagic gastroenteritis in dogs—A clinical profile. Indian Veterinary Journal, 79(4), 374–376.
Saini, R. (2011). Ozone therapy in dentistry: A strategic review. Journal of Natural Science, Biology and Medicine, 2(2), 151.
Salem, N. Y. (2014). Canine viral diarrhea: Clinical, hematologic and biochemical alterations with particular reference to in-clinic rapid diagnosis. Global Veterinaria, 13(3), 302–307.
Saravanan, S., Ramprabhu, R., Mohanapriya, T., Chitra, R., & PonnuSwamy, K. K. (2020). Retrospective study on risk factors and haemato-biochemical alterations associated with canine parvoviral enteritis. Journal of Entomology and Zoology Studies, 8, 342–346.
Shah, S. A., Sood, N. K., Wani, N., Gupta, K., & Singh, A. (2013). Haemato-biochemical changes in canine parvoviral infection. Indian Journal of Veterinary Pathology, 37(2), 131–133.
Shruti, G., & Ajay, K. (2023). Canine parvo viral enteritis in dogs: Diagnostic and therapeutic evaluation. Journal of Veterinary and Animal Sciences, 54(1), 71–78.
Snedecor, G. W., & Cochran, W. G. (1994). Statistical Methods (8th ed.). Iowa State University Press, Ames, Iowa, USA.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Indian Journal of Veterinary Sciences and Biotechnology
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
