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Home▶ Journals▶ Indian Journal of Veterinary Sciences and Biotechnology▶Archive▶Vol. 22 No. 1 (2026)▶Physiological and Haemato-Biochemical Alterations in the…
Indian Journal of Veterinary Sciences and Biotechnology
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Research Article

Physiological and Haemato-Biochemical Alterations in the Ketamine-Propofol-Isoflurane and Tiletamine-Zolazepam Isoflurane Anaesthetic Protocols in Cats

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Raisudin N Badi — Department of Veterinary Surgery and Radiology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Junagadh-362 001, Gujarat, India.
Jignesh J Vadalia — Department of Veterinary Surgery and Radiology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Junagadh-362 001, Gujarat, India.
Anil Sharma — Department of Veterinary Anatomy, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Junagadh-362 001, Gujarat, India.
Arun K Sharma — Department of Veterinary Physiology and Biochemistry, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Junagadh-362 001, Gujarat, India.
Vaibhav D Dodia — Veterinary Clinical Complex, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Junagadh-362 001, Gujarat, India.
Published 10 Jan 2026 Vol. 22 No. 1 (2026), pp. 91-95 ● Open access
❝ How to cite 🔗 https://doi.org/10.48165/ijvsbt.22.1.18
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Abstract

The present clinical study involved 12 cats of different age, sex, and breed presented for various surgeries, which were randomly  divided into two groups, each group consisting of six cats. Induction of anaesthesia was achieved by administration of ketamine @ 2  mg/kg b.wt. in combination with propofol @ 2 mg/kg b.wt., intravenously in group I and tiletamine @ 5 mg/kg b.wt. in combination  with zolazepam @ 5 mg/kg b.wt., intramuscularly in group II. It was maintained by isoflurane with 100% oxygen using a face mask  connected with small animal inhalant anaesthesia machine. Significant decrease in rectal temperature, respiration rate and plasma  total protein, and non-significant alteration in heart rate, SpO2, ALT, BUN and creatinine were observed during the maintenance phase  in both groups, but within normal physiological range. However, no significant difference was noted between groups at any point of  time in any of the parameters evaluated. Overall satisfactory outcome from the anaesthesia was achieved in both groups, yet group I  showed slightly better result than group II.

KeywordsCats, Clinico-physiological effects, Haemato-biochemical alterations, Isoflurane, Ketamine-propofol, Tiletamine-zolazepam

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  1. Abdelhakiem, M. A. H., Ahmed, A. A., Ali, M. M., Abd-Ellah, M. R., & Ali, M. A. M. (2019). Evaluation of physical and haemato-biochemical parameters after administration of different doses of propofol in xylazine-ketamine premedicated dogs. EC Veterinary Science, 4(8), 684–693.
  2. Bhowmik, T. (2016). Comparative evaluation of isoflurane, sevoflurane and ketamine anaesthesia in cats (M.V.Sc. Thesis). College of Veterinary and Animal Sciences, KVASU, Mannuthy, Kerala, India.
  3. Clarke, K. W., & Trim, C. M. (2013). Veterinary Anaesthesia (11th ed., p. 694). Elsevier Health Sciences.
  4. De Vries, A., Taylor, P. M., Troughton, G., Liu, B., Fowden, A. L., & Sear, J. W. (2013). Real-time monitoring of propofol blood concentration in ponies anaesthetized with propofol and ketamine. Journal of Veterinary Pharmacology and Therapeutics, 36(3), 258–266.
  5. Hui, T. W., Short, T. G., Hong, W., Suen, T., Gin, T., & Plummer, J. (1995). Additive interactions between propofol and ketamine when used for anaesthesia induction in female patients. Anesthesiology, 82(3), 641–648.
  6. Jimenez, C. P., Mathis, A., Mora, S. S., Brodbelt, D., & Alibhai, H. (2012). Evaluation of the quality of the recovery after administration of propofol or alfaxalone for induction of anaesthesia in dogs anaesthetized for magnetic resonance imaging. Veterinary Anaesthesia and Analgesia, 39(2), 151–159.
  7. Kilic, N. (2017). Investigation of the effect of injection anaesthesia with propofol on the haematological and biochemical parameters in cats. Kafkas University Journal of Veterinary Faculty, 23(1), 1–5.
  8. Kwon, Y. S., Jeong, J. H., & Jang, K. H. (2003). Comparison of tiletamine/zolazepam, xylazine-tiletamine/zolazepam and medetomidine-tiletamine/zolazepam anaesthesia in dogs. Korean Journal of Veterinary Clinical Medicine, 20(1), 33–41.
  9. Lee, J. Y., Son, S. J., Jang, S., Choi, S., & Cho, D. W. (2018). Antagonistic effect of flumazenil on tiletamine-zolazepam-induced anaesthesia in Beagle dogs. Veterinární Medicína, 63(12), 555–560.
  10. Moffat, K. (2008). Addressing canine and feline aggression in the veterinary clinic. Veterinary Clinics of North America: Small Animal Practice, 38(5), 983–1003.
  11. Nejamkin, P., Cavilla, V., Clausse, M., Landivar, F., Lorenzutti, A. M., Martínez, S., & Martin-Flores, M. (2020). Sedative and physiologic effects of tiletamine–zolazepam following buccal administration in cats. Journal of Feline Medicine and Surgery, 22(2), 108–113.
  12. Patel, K. D., Suthar, D. N., Jhala, S. K., Dabas, V. S., Bhanderi, D. R., & Bhatt, A. B. (2022). Effects of ketamine-midazolam and tiletamine-zolazepam as induction and isoflurane as maintenance anaesthetic agents on clinico-physiological and haemato-biochemical parameters in cats. The Pharma Innovation Journal, 11(11), 32–35.
  13. Reed, R. A., Quandt, J. E., Brainard, B. M., Copeland, J. E., & Hofmeister, E. H. (2019). The effect of induction with propofol or ketamine and diazepam on quality of anaesthetic recovery in dogs. Journal of Small Animal Practice, 60(10), 589–593.
  14. Sayyed Mohd, D. B. T. (2019). Efficacy of dexmedetomidine-ketamine-butorphanol and dexmedetomidine-ketamine-propofol for laparoscopic vasectomy in cat (M.V.Sc. Thesis). Bombay Veterinary College, MAFSU, Nagpur, Maharashtra, India.
  15. Sodagar, B. N., Patel, P. B., Barot, H. M., Sutaria, P. T., & Chaudhari, J. D. (2021). Assessment of atropine-tiletamine-zolazepam and dexmedetomidine-ketamine-butorphanol anaesthesia for ovariohysterectomy in non-descript cats. The Pharma Innovation Journal, SP-10(12), 1152–1159.
  16. Steffey, E. P., & Howland, D. (1978). Potency of enflurane in dogs: Comparison with halothane and isoflurane. American Journal of Veterinary Research, 39(4), 573–577.
  17. Willman, E. V., & Andolfatto, G. (2007). A prospective evaluation of “ketofol” (ketamine/propofol combination) for procedural sedation and analgesia in the emergency department. Annals of Emergency Medicine, 49(1), 23–30.
  18. Wycislo, K. L., Connolly, S. L., Slater, M. R., & Makolinski, K. V. (2014). Biochemical survey of free-roaming cats (Felis catus) in New York City presented to a trap-neuter-return program. Journal of Feline Medicine and Surgery, 16(8), 657–662.
  19. Zlateva, N., & Marinov, G. (2015). Effect of three anesthetic protocols on the haematological indices in cats during ovariohysterectomy. Medinform, 2(1), 184–193.

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