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Home▶ Journals▶ Indian Journal of Veterinary Sciences and Biotechnology▶Archive▶Vol. 20 No. 5 (2024)▶Evaluation of Novel Therapeutic Approach and Surgical…
Indian Journal of Veterinary Sciences and Biotechnology
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Research Article

Evaluation of Novel Therapeutic Approach and Surgical Management of Closed Cervix Pyometra in Bitches

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Chhavi Gupta — 1Department of Veterinary Gynaecology and Obstetrics, Veterinary College and Research Institute, Tirunelveli-627358, Tamil Nadu Veterinary and Animal Sciences University (TANUVAS), India
K Krishnakum — Director, Advanced Institute for Integrated Research on Livestock and Animal Sciences, Nandanam, Chennai-600035, Tamil Nadu, India
S Malmarugan — Director, Advanced Institute for Integrated Research on Livestock and Animal Sciences, Nandanam, Chennai-600035, Tamil Nadu, India
M Chellapandian — Department of Animal Nutrition, Veterinary College and Research Institute, Tirunelveli-627358, TANUVAS, Tamil Nadu, India
Published 7 Sep 2024 Vol. 20 No. 5 (2024), pp. 66-71 ● Open access
❝ How to cite 🔗 https://doi.org/10.48165/ijvsbt.20.5.12
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Abstract

The present study was conducted in the twenty-eight number of bitches aged between 2 to 6 years presented to SAC-OP-OG unit of  Madras Veterinary College Teaching Hospital with a history of inappetence, lethargy, polyuria, polydipsia and distended abdomen which  was further confirmed as pyometra by radiography and ultrasound examination. Further, the bitches were divided equally into group  I and II. Group I (n=14) was treated with Tab. Mifepristone @ 2.5 mg/kg b.wt. per OS, Tab. Cabergoline @ 5 µg/kg b.wt. per OS and Tab.  Misoprostol @ 100 µg per vaginum for 7 to 14 days. Group II (n=14) bitches directly underwent ovariohysterectomy. The assessment  of uterine distention was performed by follow-up ultrasonography on day 7, 14, 21 and 28. The blood samples were collected on day  0 (before administering treatment) and on day 7, 14 and 21 in both groups for haemato-biochemical examination. In Group I, 78.57%  and 63.63% of cases responded and conceived, respectively, in next cycle, while 9.09% cases had recurrence of pyometra. The altered  haemato-biochemical indices in Group I and II were reversed between 14 to 21 and 7 to 10 days, respectively. The study concluded that  the physiological and haemato-biochemical reversal is delayed in Group I with ovariohysterectomy, but mifepristone and cabergoline  used in Group I prove to be safe and efficient therapeutic protocol for management of closed pyometra and restoring the breeding  ability in young bitches. 

KeywordsBitchCabergolineCloprosternolClosed cervix pyometraMifepristoneMisoprostol

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