Ayurvedic Therapeutic Management of a Chronic Liver Disease With Progressed Chronic Liver Failure: A Clinical Case Study
DOI:
https://doi.org/10.48165/IRJAY.2026.90306Keywords:
Kamala, Pitta Dushti, Rakta Dushti, Ranjaka Pitta Dushti, Strotorodha and Yakrit VikaraAbstract
Chronic Liver Failure (CLF), evolving from long-standing Chronic Liver Disease (CLD), is a progressive condition marked by impaired liver function and systemic complications. In Ayurveda, it is understood as a manifestation of aggravated Pitta Dosha, particularly Ranjaka Pitta, resulting in Ama accumulation, Rakta Dushti, and Srotorodha, leading to conditions akin to Kamala, Yakritodar, or Kumbhak Kamala. This case report presents a 37-year-old male with CLF and associated features such as Mukha – Pada Shotha (facial and pedal oedema), Peeta Netra (jaundiced sclera), Daurbalya (weakness), and Vibandh (constipation). A 14-day integrative Ayurvedic protocol including Panchakarma therapies, classical formulations, and dietary modifications was administered. Marked clinical and biochemical improvements were observed post-treatment, including reduced bilirubin levels, improved haemoglobin, and relief in oedema and fatigue. The outcome highlights the efficacy of individualized Ayurvedic management in restoring Agni, correcting Pitta Dushti, and enhancing overall quality of life in CLF patients.
Downloads
References
Jalan, R., Ginès, P., Olson, J. C., Mookerjee, R. P., Moreau, R., Garcia-Tsao, G., Arroyo, V., & Kamath, P. S. (2012). Acute-on-chronic liver failure. Journal of Hepatology, 57(6), 1336–1348.
European Association for the Study of the Liver. (2018). EASL clinical practice guidelines for the management of patients with decompensated cirrhosis. Journal of Hepatology, 69(2), 406–460. https://doi.org/10.1016/j.jhep.2018.03.024
Hernaez, R., Solà, E., Moreau, R., & Ginès, P. (2017). Acute-on-chronic liver failure: An update. Gut, 66(3), 541–553.
Arroyo, V., Moreau, R., & Jalan, R. (2020). Acute-on-chronic liver failure. The New England Journal of Medicine, 382(22), 2137–2145.
Kumari, S., Laxmikant, S. D., B., S., & Khanal, S. (2022). Efficacy of integrated Ayurveda treatment protocol in type 2 diabetes mellitus: A case report. Journal of Ayurveda and Integrative Medicine, 13(1), 100512. https://doi.org/10.1016/j.jaim.2021.08.005
Chattopadhyay, K., Panniyammakal, J., Biswas, T. K., Heinrich, M., Lewis, S. A., Greenfield, S. M., Tandon, N., Kinra, S., & Leonardi-Bee, J. (2020). Effectiveness and safety of Ayurvedic medicines in type 2 diabetes mellitus management: A systematic review protocol. JBI Evidence Synthesis, 18(11), 2380–2389. https://doi.org/10.11124/JBISRIR-D-19-00350
Shukla, V., & Tripathi, R. D. (Eds.). (2013). Charaka Samhita of Agnivesa (Vol. 1, Sutra Sthana, Chapter 24, Verses 25–29, p. 325, with Vaidyamanorama Hindi commentary). Chaukhamba Sanskrit Pratishthan.
Tripathi, B. (Ed.). (n.d.). Madhavanidanam (Rogaviniscaya) of Sri Madhavakara with Madhukosa commentary by Vijayaraksita and Srikanthadatta (Vol. 1, Chapter 8, p. 322). Chaukhamba Ayurvijnana Granthamala.
Patidar, A., Mangal, G., & Sharma, S. (2022). Matra Basti—Mode of action: A conceptual study. International Research Journal of Ayurveda & Yoga, 5, 130–133. https://doi.org/10.47223/IRJAY.2022.5520
Tonde, S. S. (2023). Review of Basti. World Journal of Pharmaceutical Research, 12(9), Article 30049. https://doi.org/10.20959/wjpr202319-30049
Bagwari, M., Gupta, P., Goyal, P., Bhawana, & Mahajan, K. (2024). Various types of Bahya Basti (Local Basti). Journal of Ayurveda and Integrated Medical Sciences, 9(7), 276–284. https://doi.org/10.21760/jaims.9.7.43
Rawat, V., Kumar, V., & Verma, S. (2020). Role of Shirodhara by Brahmi Taila in essential hypertension: A conceptual study. World Journal of Pharmaceutical and Medical Research, 6(10), 154–158.
Sojitra, D., Shukla, H., Kanakhara, B., Gosai, R., & Bhimani, B. (2017). Lifestyle disorder related. World Journal of Pharmaceutical Research, 6(7). https://doi.org/10.20959/wjpr20177-8725
Chowdhury, B. R. (n.d.). World's best: The D.I.P. diet. https://biswaroop.com/dipdiet/
Garud, S., Chaudhary, A., & Kotecha, M. (2017). Pathya Apathya: A peculiarity of Ayurveda. International Journal of Ayurvedic and Herbal Medicine, 7(4), 2635–2642. https://doi.org/10.18535/ijahm/v7i4.01
Suman, & Joshi, N. K. (2024). Millets: Forgotten grains with potential health benefits in Ayurveda with special reference to Kodrava. Journal of Ayurveda and Integrated Medical Sciences, 9(7), 230–236. https://doi.org/10.21760/jaims.9.7.35
Brodovicz, K. G., McNaughton, K., Uemura, N., Meininger, G., Girman, C. J., & Steven, H. (2009). Reliability and feasibility of methods to quantitatively assess peripheral oedema. Clinical Medicine & Research, 7(1–2), 21–31. https://doi.org/10.3121/cmr.2009.825
Elman, S., Hynan, L. S., Gabriel, V., & Mayo, M. J. (2010). The 5-D itch scale: A new measure of pruritus. British Journal of Dermatology, 162(3), 587–593.
Larrey, D. (2000). Drug-induced liver diseases. Journal of Hepatology, 32(Suppl. 1), 77–88. https://doi.org/10.1016/S0168-8278(00)80417-1
Marjot, T., Ray, D. W., Williams, F. R., Tomlinson, J. W., & Armstrong, M. J. (2021). Sleep and liver disease: A bidirectional relationship. The Lancet Gastroenterology & Hepatology, 6(10), 747–757. https://doi.org/10.1016/S2468-1253(21)00169-2Panda, A. K., Sahoo, P. K., & Nayak, B. P. (2020). Pathya & Apathya (wholesome & unwholesome diet and regimen) in Yakrit Kshaya (liver cirrhosis): A narrative review. Journal of Ayurveda and Integrated Medical Sciences, 5(5), 419–425. https://www.jaims.in/jaims/article/view/1077
Patel, M. V., Patel, K. B., Gupta, S., Michalsen, A., Stapelfeldt, E., & Kessler, C. S. (2015). A complex multiherbal regimen based on Ayurveda medicine for the management of hepatic cirrhosis complicated by ascites: Nonrandomized, uncontrolled, single-group, open-label observational clinical study. Evidence-Based Complementary and Alternative Medicine, 2015, Article 613182. https://doi.org/10.1155/2015/613182
Fernández, T., Viñuela, M., Vidal, C., & Barrera, F. (2022). Lifestyle changes in patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis. PLOS ONE, 17(2), e0263931. https://doi.org/10.1371/journal.pone.0263931
Nigam, R., & Garg, P. (2022). Antimicrobial studies on aqueous and ethanolic extract of root, stem and leaves of Phyllanthus niruri (Bhumi Amla): Hepatoprotective medicinal plant. Research Journal of Pharmacy and Technology, 15(11). https://doi.org/10.52711/0974-360X.2022.00889
Bhowmik, D., Sampath Kumar, K. P., Srivastava, S., Paswan, S., & Sankar, A. (2012). Traditional Indian herb Punarnava and its medicinal importance. Journal of Pharmacognosy and Phytochemistry, 1(1), 52–58.
Solanki, V., Pillai, A. P. G., Dave, K. K., & De, S. (2017). Pharmaceutical analysis of Dronpushpi (Leucas cephalotes). Pharma Science Monitor, 8(2).
Taru, P., Syed, S., Kute, P., Shikalgar, M., Kad, D., & Gadakh, A. (2022). Dashamool: A systematic overview. GIS Zeitschrift für Geoinformatik, 9, 1334–1345.
Bhattacharjee, A., & Shashidhara, S. C. (2012). Phytochemical and ethno-pharmacological profile of Crataeva nurvala Buch.-Ham. (Varuna): A review. Asian Pacific Journal of Tropical Biomedicine, 2(2 Suppl.), S1162–S1168.
Bhola, S., & Rao, M. P. (2016). Are Rasapanchaka physical effects or pharmacological effects? A detailed review. World Journal of Pharmaceutical Research, 5, 404–415.
Angeli, P., Bernardi, M., Villanueva, C., Francoz, C., Mookerjee, R. P., Trebicka, J., Krag, A., Laleman, W., Ginès, P., & EASL Clinical Practice Guidelines Panel. (2018). EASL clinical practice guidelines for the management of patients with decompensated cirrhosis. Journal of Hepatology, 69(2), 406–460. https://doi.org/10.1016/j.jhep.2018.03.024
Tan, C.-K., Goh, G. B.-B., Youn, J., Yu, J. C.-K., & Singh, S. (2021). Public awareness and knowledge of liver health and diseases in Singapore. Journal of Gastroenterology and Hepatology, 36(8), 2135–2141. https://doi.org/10.1111/jgh.15496
Iwakiri, Y., & Trebicka, J. (2021). Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy. JHEP Reports, 3(4), 100316. https://doi.org/10.1016/j.jhepr.2021.100316
Snowdon, V. K., Guha, N., & Fallowfield, J. A. (2012). Noninvasive evaluation of portal hypertension: Emerging tools and techniques. International Journal of Hepatology, 2012, 691089. https://doi.org/10.1155/2012/691089
Wright, A. S., & Rikkers, L. F. (2005). Current management of portal hypertension. Journal of Gastrointestinal Surgery, 9, 992–1005.
Lu, W., Qu, J., Yan, L., et al. (2023). Efficacy and safety of mesenchymal stem cell therapy in liver cirrhosis: A systematic review and meta-analysis. Stem Cell Research & Therapy, 14, 301. https://doi.org/10.1186/s13287-023-03518-x
Kibble, H., & Shawcross, D. L. (2023). The microbiome in portal hypertension. Clinical Liver Disease, 22(2), 70–74. https://doi.org/10.1097/CLD.0000000000000051
Bell, A. W. (2022). Personalized medicine for liver disease: From molecular mechanisms to potential targeted therapies. Journal of Personalized Medicine, 12(5), 663. https://doi.org/10.3390/jpm12050663
Rajakumar, A., Appuswamy, E., Kaliamoorthy, I., & Rela, M. (Year). Renal dysfunction in cirrhosis: Critical care management. Indian Journal of Critical Care Medicine.
