Physiological Effect of Caffeic Acid on Gouty Arthritis Induced by Monosodium Urate in Rats

Authors

  • Noora H AL-shaheen Department of Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, University of Basrah, Basrah, Iraq
  • Zainab A H Al-Mousawi Department of Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, University of Basrah, Basrah, Iraq
  • M Praveena Department of Livestock Products Technology, College of Veterinary Science, Tirupati.
  • V Bhuvana Sri Department of Livestock Products Technology, College of Veterinary Science, Tirupati.
  • P Naswar Khan Department of Livestock Products Technology, College of Veterinary Science, Tirupati.
  • M Kalyana Chakravarthi Senior Scientist & Head, AICRP on Pigs, Tirupati Sri Venkateswara Veterinary University, Tirupati.

DOI:

https://doi.org/10.48165/ijapm.2026.42.02.13

Keywords:

Consumer, consumption pattern, meat, food safety

Abstract

Gouty arthritis is a metabolic and inflammatory condition linked to hyperuricemia and systemic inflammation. Although allopurinol is the traditional clinical treatment, it is usually used to lower uric acid levels; it generally carries risks of hepatic and renal damage. This study sought to bridge this therapeutic gap by investigating the multi-target effects of Caffeic Acid in a rat model of gouty arthritis. Methodology: twenty -four adult male rats were randomly divided into four groups: Negative Control, Gout-Induced by monosodium urate crystals, Gout + Allopurinol and Gout + Caffeic acid. The treatments were given orally at a dose of 100 mg/kg for 30 consecutive days. Radiographic imaging was performed to evaluate joint structural integrity. Serum was analyzed for uric acid, WBC count, ESR, oxidative stress markers, CRP, cortisol, along with renal safety indicators such as creatinine and hepatic enzymes (ALT, AST). Results: Metabolic and inflammatory abnormalities were substantial in the Gout group, characterized by marked elevation in Uric Acid, WBC & ESR. Allopurinol significantly reduced uric acid but had a moderate effect on systemic inflammatory indicators (ESR and WBC). It is worth mentioning that Caffeic Acid demonstrated superior therapeutic efficacy, achieving a dramatic reduction in uric acid alongside complete normalization of WBC and ESR values. Moreover, Caffeic Acid had a better safety profile with reduced ALT, AST and Creatinine levels than Allopurinol. We concluded that caffeic acid has strong hypouricemic activity, systemic anti-inflammatory, antioxidant benefits and may be a safer bio-alternative for the treatment of gouty arthritis.

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Published

2026-06-03

Issue

Vol. 42 No. 2 (2026): Indian Journal of Animal Production and Management(Apr-Jun)

Section

Research Article

How to Cite

Physiological Effect of Caffeic Acid on Gouty Arthritis Induced by Monosodium Urate in Rats. (2026). Indian Journal of Animal Production and Management, 42(2), 85-91. https://doi.org/10.48165/ijapm.2026.42.02.13