METABOLIC AND HORMONAL PROFILE ALTERATIONS IN INDIAN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME: A CROSS SECTIONAL COMPARATIVE STUDY
DOI:
https://doi.org/10.48165/abr.2026.28.01.24Keywords:
Cardiovascular risk, dyslipidemia, hyperandrogenism, Indian women, metabolic syndrome, polycystic ovarian syndromeAbstract
Polycystic ovarian syndrome (PCOS) globally affects 8-20% of reproductive age women, with significant metabolic and hormonal implications. Comprehensive biochemical profiling studies in Indian women remain limited despite the condition's high prevalence in Indian population. This cross sectional study recruited 100 women aged 18-40 years from Malla Reddy Hospital, Hyderabad, India. Fifty women diagnosed with PCOS as per Rotterdam criteria were compared with 50 age-matched healthy controls. Fasting blood samples were analysed for glucose, lipid profile (total cholesterol, triglycerides, LDL and HDL), and hormonal markers (testosterone, prolactin, T3, T4 and TSH). Statistical analysis included descriptive statistics and independent t-tests. All measured parameters showed significant differences betweenthe groups(p<0.01).WomenwithPCOSdemonstratedsevere metabolic dysfunction, as evidenced by highglucose levels(144.06 ±45.17 vs. 94.86 ± 9.12 mg dL-1), indicating hyperglycemia. Dyslipidemia was prominent, with total cholesterol elevated by 53% (222.52 ± 31.58 vs 145.66 ± 25.83 mg dL-1), triglycerides by 51% (157.18 ± 19.74 vs 103.84 ± 23.71 mg dL-1), and LDL by 52% (135.62 ± 23.46 vs 89.12 ± 13.23 mg dL-1). HDL was critically reduced by 43% (28.10 ± 12.76 vs 49.20 ± 6.70 mg dL-1). Hormonal analysis revealed hyper androgenism with testosterone levels 80% higher (72.14 ± 35.25 vs 40.10 ± 12.94 ng dL-1), and prolactin elevated by 139% (34.27 ± 21.83 vs 14.36 ± 5.09 ng mL-1). Majority of PCOS women (94%) metmet abolicsyndro mecriteria. Indian women with PCOS exhibit comprehensive metabolic syndrome characterized by severe dyslipidemia, hyperglycemia, and hormonal imbalances. Early screening and integrated management approaches are urgently needed to prevent long-term cardiovascular and metabolic complications in the Indian population.
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